i am using Fluent UI in my project.
I initializing my button with this simple code in javascript:
iconProps: {
iconName: 'NewFolder',
styles: {
root: {
color: 'orange'
},
}
},
and i can override default color to asked one.

My question is, how to set mouse hover color over button? 
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Answer
For IconButton, DefaultButton and PrimaryButton you have property root for default button style, rootHovered, rootChecked etc. for different states.
<IconButton
iconProps={{ iconName: 'NewFolder' }}
styles={{
root: { color: 'blue' },
rootHovered: { color: 'orange' },
}}
/>
Codepen working example
Button styles also might help.